Cardiovascular

SERVICES

NHP Service Overview Central Nervous System Ophthalmology Obesity Diabetes Dyslipidemia Cardiovascular Hypertension Chronic Kidney Disease NAFLD/NASH Fibrosis Oncology Bone Diseases Osteoporosis Age-related hearing loss Mice Model Antibacterial

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Sichuan PriMed Shines Bio-tech Co., Ltd., headquartered in Chengdu, China, is a Non-human Primate CRO with extensive research experiences of 12 years (2005-2017). PriMed Shines provides highest service to our clients in our 400,000 ft2 fully AAALAC accredited facilities.

Cardiovascular

Cardiovascular Disease

Cardiovascular disease is the number one cause of death globally. Innovative new therapeutics that can modify or even reverse heart failure progression, especially diastolic dysfunction, are needed to reduce the disease burden in the general population.
However, research into the development of novel and improved treatments is complicated by a lack of preclinical CVD models. PriMed Shines provides highly translatable NHP models and key technologies for CVD to help progress your novel agents into the clinic.
Our CVD Imaging Translational Technology Platform provides heart failure, hypertension NHP models and multiple imaging techniques.

NHP Model

With longitudinal (2-5 years) medical records, including echo and MRI, blood pressure, metabolic status, renal function, clinical pathology, body weight, food intake, cardiac biomarkers, vet treatment and dosing record.

Heart failure

Diastolic Dysfunction and Preserved Left Ventricular Ejection Fraction with Aged, Hypertention, Pre-Diabetic/Diabetic Rhesus Monkeys Using Imaging and Circulating Biomarkers.
Diastolic Dysfunction and Preserved Left Ventricular Ejection Fraction with Aged, Hypertention, Pre-Diabetic/Diabetic, Chronic Kidney Disease(G3a-G3b) Rhesus Monkeys Using Imaging and Circulating Biomarkers.
Systolicc Dysfunction and Reduced Left Ventricular Ejection Fraction with Aged, Dyslipidimia and Atherosclerosis Rhesus Monkeys Using Imaging and Circulating Biomarkers.
With comorbidities: Diabetes, HTA, Age, Hypertension, Chronic kidney disease, pulmomary edema, dyslipidemia, Atherosclerosis

Spontaneous Chronic Heart Failure-Systolic Dysfunction

Spontaneous Chronic Heart Failure-Diabetic Diastolic Dysfunction

Spontaneous Diffuse Myocardial Fibrosis

Myocardial Ischemia

Atherosclerosis

Rhythm disorders

Tachycardia
Arrhythmia

Drugs/references tested

Entresto, Pioglitazone, GPR40 agonist, SGLT2 Inhibitor, Bydureon, Dulaglutide, Atorvastatin, Simvastatin, Ezetimibe, PCSK9 Inhibitor, Omega-3 fatty acid, Orlistat, Enalapril

Comparison of Human and NHP Cardiovascular Disease

Mice Model

Transverse aortic constriction (TAC)

Ischemia/reperfusion

Permanent coronary ligature

Microembolization

Pacing

PriMed Posters and Publications

AHA 66th Anaheim, CA,

Naturally Occurring Hypertension is Related to Cardiac Diastolic Dysfunction in Rhesus Monkeys

ADA 77th Scientific Sessions, San Diego

488-P: A Plant-Derived Drug Improves the Cardiac Function of Monkeys with Heart Failure and Type 2 Diabetes
2427-PUB: Determination and Evaluation of Hypertension in a Nonhuman Primate Model of Type 2 Diabetes
1993-P: Adaptation of Slow- and Fast-twitch Skeletal Muscles to Type 2 Diabetes Mellitus (T2DM) in Diabetic Rhesus Monkeys: an Initial Experience with Non-contrast MRI Microcirculation Mapping Techniques.
485-P: Application of CMR T1ρ Mapping and T1 Mapping in Diagnosis of Diffuse Myocardial Fibrosis in Type 2 Diabetes Mellitus Rhesus Monkeys with Myocardial Diastolic Dysfunction.

ADA 76th Scientific Sessions, New Orleans

217-OR: Diffuse Myocardial Fibrosis Quantified by T1 Mapping at 3 T Increases in Early Diabetic Cardiomyopathy: A Preclinical Validation Study in Nonhuman Primates

ICO 2016, Vancouver

Diagnosis Of Naturally-occurring Non-alcoholic Steatohepatitis (NASH) In Obese Rhesus Monkeys Using Histopathology Criteria
Quantification Of Hepatic Fat In Naturally-occurring Nonalcoholic Fatty Liver Disease (NAFLD) In Obese Rhesus Monkeys Using Dual-energy CT (DECT)

ADA 75th Scientific Sessions, Boston

2891-PO: The Characteristics of Blood Pressure of Type 2 Diabetic Monkeys
2122-P: Effects of a Long-Acting Formulation of Exenatide on Glucose and Weight Control in Type 2 Diabetic Rhesus Monkeys
1840-P: Blood-Brain Barrier Permeability Increased in Rhesus Monkeys with Spontaneous T2DM: A Non-Invasive MRI Study

More information about posters and publications