Non-human primates develop spontaneous obesity, metabolic syndrome, and T2DM with characteristics that are extraordinarily like those of humans. Obese, dysmetabolic, and diabetic NHPs also develop hepatic pathology with characteristics of NAFLD/NASH.
PriMed Shines rhesus colony has been studied longitudinally for 7 years under consistent dietary, procedures, and environmental conditions. This consistency is key to the characteristics of obesity, metabolic syndrome, and T2DM, and provides a quickstart for the efficacy study of obesity treatments.
-- Breeding center: n=~3000 rhesus macaques (macaca mulatta)
-- n=~500 obese rhesus macaques
-- Longitudinal body weight data (monthly)
-- Dual Energy X-ray absorptiometry (DEXA) and for body composition
-- Longitudinal long term studies
-- Long enough life span for complication development (and reversal/treatment effects)
-- Highly controlled and consistent environment
-- More valid than rodents for projecting human outcomes
-- Combine pharmacokinetics, efficacy and safety
-- Discover new targets and mechanisms of action
-- Use of multiple outcome measures for validation of future clinical plan
1993-P: Adaptation of Slow- and Fast-twitch Skeletal Muscles to Type 2 Diabetes Mellitus (T2DM) in Diabetic Rhesus Monkeys: an Initial Experience with Non-contrast MRI Microcirculation Mapping Techniques.
Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Nonhuman Primates (NHP’s) is Comparable to Humans for Metabolic Features, Histology and Imaging
Quantification Of Hepatic Fat In Naturally-occurring Nonalcoholic Fatty Liver Disease (NAFLD) In Obese Rhesus Monkeys Using Dual-energy CT (DECT)
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