Abstract

Objective: The aim of this study was to test the obesity-type 2 diabetes mellitus (T2DM) link in the context of longitudinal changes in body weight during the progression to diabetes in mature adult nonhuman primates (NHP)……

Conclusions: The natural progression from pre-DM to overt T2DM is caused neither by the amount of excess body weight at DM onset nor by the proximate increases in body weight/adiposity during the pre-DM period of impaired glucose tolerance. Obesity was, however, essential preceding all NHP cases that developed T2DM.

Fig. 1.  Body weight, % body fat, and lean body mass in adult male rhesus monkeys over the age of 8 years, including normal animals (◇). prediabetic (■), and overtly diabetic monkeys (▲). Body weight was significantly and positively correlated with % BF (r = 0.80, P < 0.001) (A) and with FFM (r = 0.75, P < 0.001(B). FFM and % BF were also associated (r = 0.31, P < 0.001) (C).

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