Abstract

Background: Animal models provide insights into the diabetic nephropathy pathogenesis, however, available rodent models do not mirror the heterogeneity of lesions in type 2 diabetic (T2DM) patients, and do not progress to end stage renal disease. Previous studies showed that spontaneously obese T2DM rhesus monkeys develop many of the features of human diabetic glomerulopathy, and may progress to ESRD. Here, in order to further characterize diabetic glomerulopathy in this model, we used electron microscopic stereology.

Fig.2.  ectron micrographs (11,000 ×) of glomeruli from a non-diabetic (A) and a diabetic (B and C) monkeys. Increased mesangial (Mes) matrix (asterisk) and glomerular basement membrane (GBM) thickening is evident in B and C. Abbreviations: Cap = capillary;

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