Abstract

Objective: Changes in vasomotion may precede other global indices of autonomic dysfunction that track the onset and progression of diabetes. Recently we showed that baseline spectral properties of vasomotion can discriminate among normoglycemic (N), prediabetic (PreDM), and diabetic (T2DM) nonhuman primates. In this study, our aims were 1. To determine the time-dependence and complexity of the spectral properties of vasomotion in three metabolic groups of monkeys; 2. To examine the effects of heat-provoked vasodilatation on the power spectrum; and 3. To compare the effects of exogenous insulin on the vasomotion.

Keywords: Vasomotion; Diabetes; Monkeys.

Fig. 1： Sample heat treatment data for a normoglycemic subject. Top: Flow rate, Bottom: temperature (°C)

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