Abstract

The euglycemic glucose clamp is the reference method for assessing insulin sensitivity in humans and animals. However, clamps are ill-suited for large studies because of extensive requirements for cost, time, labor, and technical expertise. Simple surrogate indexes of insulin sensitivity/resistance including quantitative insulin-sensitivity check index (QUICKI) and homeostasis model assessment (HOMA) have been developed and validated in humans. However, validation studies of QUICKI and HOMA in both rats and mice suggest that differences in metabolic physiology between rodents and humans limit their value in rodents. Rhesus monkeys are a species more similar to humans than rodents.

Keywords: Euglycemic, Rhesus monkeys

Fig.2.Linear correlations between SI clamp and various surrogate indexes of insulin sensitivity/resistance. Dark circles (F), Clamps from lean monkeys. White squares (口), Clamps from obese monkeys. The solid line represents a regression line for surrogate indexes and SI Clamp for the entire cohort (199 clamps). Pearson correlation coefficient (r) with corresponding P values are shown. A, Results for QUICKI. B, Results for HOMA. C, Results for Log HOMA. D, Results for 1/HOMA. E, Results for 1/Fasting insulin.

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